Table 1.
Patient demographics and clinicopathologic characteristics
| Items | Value (%) | LOX expression
|
P-valuea | |
|---|---|---|---|---|
| Negative (n=92), n (%) | Positive (n=92), n (%) | |||
| Age (mean ± SD, years) | 57.9±12.9 | |||
| Gender | 0.009 | |||
| Male | 132 (71.7) | 74 (80.4) | 58 (63.0) | |
| Female | 52 (28.3) | 18 (19.6) | 34 (37.0) | |
| Tumor location | 0.768 | |||
| Distal stomach | 98 (53.3) | 50 (54.3) | 48 (52.2) | |
| Non-distal stomach | 86 (46.7) | 42 (45.7) | 44 (47.8) | |
| Histological grade | 0.496 | |||
| 1/2 | 46 (25.0) | 21 (22.8) | 25 (27.2) | |
| 3/4 | 138 (75.0) | 71 (77.2) | 67 (72.8) | |
| Tumor size (tumor area, cm2)b | 0.135 | |||
| <16 | 76 (46.3) | 46 (51.7) | 30 (40.0) | |
| ≥16 | 88 (53.7) | 43 (48.3) | 45 (60) | |
| Serosal invasion | 0.002 | |||
| No (T0, T1, T2) | 27 (14.7) | 21 (22.8) | 6 (6.5) | |
| Yes (T3, T4) | 157 (85.3) | 71 (77.2) | 86 (93.5) | |
| Lymph node metastasis | <0.0001 | |||
| No (N0) | 53 (28.8) | 40 (43.5) | 13 (14.1) | |
| Yes (N1, N2, N3) | 131 (71.2) | 52 (56.5) | 79 (85.9) | |
| Distant metastasis | 0.054 | |||
| M0 | 177 (96.2) | 91 (98.9) | 86 (93.5) | |
| M1 | 7 (3.8) | 1 (1.1) | 6 (6.5) | |
| TNM stages | <0.001 | |||
| Early (stages I, II) | 58 (31.5) | 42 (45.7) | 16 (17.4) | |
| Advanced (stages III, IV) | 126 (68.5) | 50 (54.3) | 76 (82.6) | |
| Surgery | 0.519 | |||
| Subtotal resection | 159 (86.4) | 81 (88) | 78 (84.8) | |
| Non-subtotal resection | 25 (13.6) | 11 (12) | 14 (15.2) | |
| Chemotherapy | 0.039 | |||
| No | 35 (19.0) | 23 (25) | 12 (13) | |
| Yes | 149 (81.0) | 69 (75) | 80 (87) | |
| Recurrence | <0.001 | |||
| No | 124 (67.4) | 82 (89.1) | 42 (45.7) | |
| Yes | 60 (32.6) | 10 (10.9) | 50 (54.3) | |
| Recurrence locationc | 0.024 | |||
| Local–regional | 37 (61.7) | 3 (30.0) | 34 (68.0) | |
| Distant | 23 (38.3) | 7 (70.0) | 16 (32.0) | |
Notes:
a
Bold indicates values with a significant difference (P<0.05).
b
Analysis was performed based on 164 patients with complete data of tumor size.
c
In all, 60 recurrent cases were included.
Abbreviation: LOX, lysyl oxidase.