Table 2.
Relationship between LOX expression and stromal parameters
| Stromal parameters | n (%) | LOX expression
|
P-valuea | |
|---|---|---|---|---|
| Negative (n=92), n (%) | Positive (n=92), n (%) | |||
| Infiltrating macrophage density | ||||
| Low | 125 (67.9) | 69 (75) | 56 (60.9) | 0.04 |
| High | 59 (32.1) | 23 (25) | 36 (39.1) | |
| MVD | ||||
| Low | 42 (22.8) | 27 (29.3) | 15 (16.3) | 0.035 |
| High | 142 (77.2) | 65 (70.7) | 77 (83.7) | |
| Neovessel maturity (%) | 61.6±18.5 | 73.3±22.3 | ||
| Low | 87 (47.3) | 50 (42.2) | 55 (54.3) | 0.038 |
| High | 97 (52.7) | 37 (59.8) | 42 (45.7) | |
| MMP-9 expression | ||||
| Negative | 92 (50.0) | 59 (64.1) | 33 (35.9) | <0.001 |
| Positive | 92 (50.0) | 33 (35.9) | 59 (64.1) | |
| Type IV collagen | ||||
| Negative | 92 (50.0) | 39 (42.4) | 53 (57.6) | 0.039 |
| Positive | 92 (50.0) | 53 (57.6) | 39 (42.4) | |
Note:
a
Bold indicates values with a significant difference (P<0.05).
Abbreviations: LOX, lysyl oxidase; MVD, microvessel density; MMP-9, matrix metalloproteinase 9.