Table 1.
Summary of recently described clinical associations and tissue expression of angiogenic factors in aGVHD.
| Angiogenic Factor |
Circulating Level in aGVHD |
Clinical Associations | Cellular/Tissue Expression in aGVHD |
|---|---|---|---|
| EGF | Low | Decreases in patients with no response to steroids at day 28 | Unknown |
| VEGF-A | Low | Increases in patients with complete response to steroids at day 28 | Megakaryocytes, likely others |
| PlGF | High | Highest in patients with aGVHD after HCT from unrelated donors compared to sibling donors | Increased in aGVHD skin, decreased in aGVHD colon compared to normal controls |
| FS | High | Elevated levels associated with mortality at 6 months | Unknown |