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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Neuroimage. 2018 Feb 1;166:285–292. doi: 10.1016/j.neuroimage.2017.10.068

Figure 1. Brain regions exhibiting a quadratic effect of Aβ on Activation to the Hard Compared to Categorical Conditions.

Figure 1

Aβ SUVR shows a nonlinear association to BOLD activation in bilateral angular/temporal gyri and medial frontal gyrus. Compared to individuals with lower SUVR, slightly elevated SUVR is associated with hyperactivation. Individuals with greater SUVR show hypoactivation. The nonlinear BOLD activation effect remains the same after controlling for gray matter volume and thickness. Blue scale represents t-values from the negative quadratic effect. Quadratic lines shown with 95% confidence intervals.