Table 4.
Correlation analyses between Gb3 isoforms (normalized to brain weight) and α-Gal A activity, α-Gal A 46 kDa active species/Actin, or p129S-α-syn 17 kDa monomer/Actin.
| Correlation (Spearman r) | |||
|---|---|---|---|
| Isoform (normalized to brain weight) | α-Gal A activity | α-Gal A 46 kDa/Actin | α-syn p129S monomer/Actin |
| C14:0 | −0.3066, p=0.0340* | −0.245, p=0.0932 | 0.1611, p=0.2740 |
| C16:0 | −0.06389, p=0.6696 | 0.1247, p=0.4035 | −0.255, p=0.0837 |
| C18:0 | −0.0906, p=0.5447 | −0.01833, p=0.9027 | −0.3197, p=0.0285* |
| C20:0 | 0.005699, p=0.9693 | −0.2022, p=0.1681 | 0.1764, p=0.2305 |
| C22:0 | −0.2873, p=0.0477* | −0.4596, p=0.0010* | 0.1908, p=0.1939 |
| C24:0 | −0.3598, p=0.0120* | −0.4344, p=0.0020* | 0.307, p=0.0338* |
| C26:0 | −0.3097, p=0.0.0322* | −0.1175, p=0.4264 | 0.3362, p=0.0195* |
| C16:1 | 0.02795, p=0.8504 | −0.1604, p=0.2762 | −0.1151, p=0.4361 |
| C18:1 | −0.1413, p=0.3434 | −0.126, p=0.3989 | −0.1893, p=0.2026 |
| C20:1 | −0.09299, p=0.5296 | −0.04797, p=0.7461 | −0.1162, p=0.4317 |
| C22:1 | −0.3409, p=0.0178* | −0.2959, p=0.0412* | 0.1145, p=0.4384 |
| C24:1 | −0.2751, p=0.0584 | −0.3075, p=0.0335* | 0.02146, p=0.8849 |
| C26:1 | −0.3035, p=0.0360* | −0.1929, p=0.1889 | 0.4037, p=0.0044* |
| C22:2 | −0.2233, p=0.1272 | −0.1766, p=0.2299 | 0.1105, p=0.4547 |
| C24:2 | −0.2303, p=0.1154 | −0.3213, p=0.0260* | 0.03543, p=0.8111 |
| C(16:0)OH | 0.1511, p=0.3053 | 0.1515, p=0.3039 | 0.08367, p=0.5718 |
| C(18:0)OH | −0.1864, p=0.2047 | −0.1405, p=0.3410 | 0.3052, p=0.0349* |
| C(20:0)OH | −0.2564 p=0.0786 | −0.169, p=0.2509 | 0.2553, p=0.0799 |
| C(22:0)OH | −0.04855, p=0.7432 | −0.2223, p=0.1288 | 0.1969, p=0.1797 |
| C(24:0)OH | −0.3352, p=0.0199* | −0.3352, p=0.0199* | 0.5028, p=00003* |
| C(22:1)OH | −0.0261, p=0.8602 | −0.08735, p=0.5550 | 0.2111, p=0.1497 |
| C(24:1)OH | −0.2239 p=0.1260 | −0.2571, p=0.0777 | 0.1023, p=0.4889 |
| C(16:0)Me | −0.3709, p=0.0094* | −0.2457, p=0.0923 | 0.01978, p=0.8938 |
| C(18:0)Me | −0.01656, p=0.9110 | −0.1558, p=0.2903 | 0.1091, p=0.4606 |
| C(20:0)Me | −0.3089, p=0.0326* | −0.2905, p=0.0451* | 0.3642, p=0.0109* |
| C(22:0)Me | −0.2353, p=0.1074 | −0.3237, p=0.0248* | 0.04717, p=0.7502 |
| C(24:0)Me | −0.1975, p=0.1785 | −0.2055, p=0.1612 | 0.3624, p=0.0114* |
| C(22:1)Me | 0.1429, p=0.3326 | −0.009977, p=0.9463 | 0.3725, p=0.0091* |
| C(24:1)Me | −0.05596, p=0.7056 | −0.155, p=0.2929 | 0.02885, p=0.8457 |
Correlations were performed using non parametric Spearman’s rho test and stepwise multiple linear regressions.
*
indicates significant correlations, with significance established a priori at p<0.05.