A, S-IRA evoked by PTZ (75 mg/kg, i.p.) was significantly reduced in transgenic DBA/1 mice with photostimulation of 5-HT neurons in the DR at 9 mW for 15 min (n = 6) as compared with that in those transgenic DBA/1 mice without photostimulation (n = 6). B, box plots show that the latency to PTZ-evoked seizures was not affected by photostimulation as compared with that in the absence of photostimulation. Blank bars, the incidence of S-IRA or latency to seizures in the absence of photostimulation; red bars, the incidence of S-IRA or latency to seizures in the presence of photostimulation. N-PS, no photostimulation; PS, photostimulation; PTZ, pentylenetetrazole. See figure 2 for photostimulation parameters.
* p < 0.05: Significantly different from PTZ treatment alone.