Table 3.

Studies on combined miRNAs predicting the prognosis of ccRCC.

Sources	Combination	Ref	Findings
Clinical	miR-21 miR-126	[30]	Improving sensitivity and specificity in predicting CSS
	miR-21 miR10b	[31]	The ratio of miR-21/miR10b is associated with tumour nuclear grade, TNM stage, and survival; the ratio is an independent prognostic factor in metastasis-free patients
	miR-21 miR-126 miR-221	[33]	The specificity of CRS for high risk patients is 90%, while for the low-risk patients it is 87%
	miR-125b and TNM stage	[16]	Markedly improving prognostic accuracy
Cell and Clinical	miR-141-3p miR-145-5p	[32]	Cooperative effect on migration and regulation of HS6ST2 and LOX, of which the latter is a strong prognostic factor for OS

ccRCC, clear cell renal cell carcinoma; CSS, cancer-specific survival; CRD, cancer related death; CRS, combined risk score; TT, tumor thrombus; OS, overall survival; DFS, disease-free survival; ND, no data; TNM, tumor-node-metastasis.