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. 2017 Dec 11;114(52):E11293–E11302. doi: 10.1073/pnas.1711243115

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Fig. 5. — Urea and its transporter are elevated in low-Vonsattel grade HD human brain. Cerebellar tissue from Vonsattel pathological grade 0 or 1 HD cases (n = 7) and controls (n =7) was quantified for (A) urea (nanomole urea per milligram protein), (B) SLC14A1 transcripts (relative levels, normalized to the geometric mean of SDHA and TRIP11 reference genes), and (C) UTB protein (relative levels, normalized to beta tubulin). The Western blot underlying the data displayed in C is shown in D. The mean, quartiles, and one-way ANOVA P values are indicated. Urea and UTB protein levels were significantly higher on average in HD patient cerebellum compared with non-HD controls (*P < 0.05).