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. 2017 Dec 11;114(52):E11257–E11266. doi: 10.1073/pnas.1714640114

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Copyright © 2017 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 1. — Off-target scores using the ambiguous genome approach. (A) Distribution of aggregate off-target scores in the reference and ambiguous genomes for human-genome–targeting, viral-genome–targeting, and nontargeting gRNAs. (B) Change in aggregate off-target score between ambiguous and reference genomes. (C) Distribution of off-target sites by number of mismatches. (D) Ratio of the number of off-target sites in ambiguous genomes compared with the reference genome stratified by the number of off-target sites in the reference genome. The y axis shows the ratios for each gRNA, whereas the x axis shows the number of off-target sites in the reference genome.