Fig. 1.
Resource limitation prevents the emergence of drug resistance. (A) Mice were assigned to each resource treatment and inoculated with 106 pyrimethamine-susceptible parasites. Rebounding parasite populations were genotyped (Fig. S3) and injected into a second drug-treated mouse to assess their phenotypic resistance. All parasites that were genotypically resistant and underwent phenotypic testing were found to be phenotypically resistant. (B) Proportion of mice in which parasites rebounded (light red, thin-lined bar) and which were confirmed to be either genetically or phenotypically resistant (dark red, thick-lined bar). Error bars represent the 95% confidence interval around the proportion as calculated from a binomial distribution. n, number of mice included in the analysis.