Fig. 3.

Resource limitation improves host health and prevents the transmission of drug resistance in mice inoculated with both drug-susceptible and drug-resistant parasites. Red blood cell dynamics of individual mice (A and B; solid lines) and the probability of resistant parasites transmitting to mosquitoes (C and D; dashed lines) in mice infected with both susceptible and drug-resistant parasites (S_AJ and R_AS) and either supplemented with resources (A and C; gray background, pABA⁺) or not (B and D; white background, pABA⁻) are shown. All mice were administered pyrimethamine treatment (green bar). Limitation of pABA was associated with less anemia (total red blood cell density, resource treatment: F_1,17 = 24.3; P < 0.001, linear regression). Note that these data are from all (A and B) or a subset (C and D) of the infections shown in Fig. 2 A and B.