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View full-text article in PMC

. 2017 Dec 11;114(52):13804–13809. doi: 10.1073/pnas.1716097115

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Fig. 3. — Examples showing the effects of letrozole (A and B) or vehicle (C and D) infusion into the median eminence on EB-induced GnRH (Left column) and kisspeptin (Right column) surges, examined using microdialysis in OVX female monkeys. While in A–D, EB was injected 36 h before sample collection, in E and F, only oil (vehicle for EB) was injected 36 h before the start of dialysate collection. Both GnRH and kisspeptin levels during the first 5.7 h in EB-injected animals (A–D) were higher than those in oil controls (E and F, see also Table S1), indicating EB induced GnRH and kisspeptin surges. In EB-treated animals letrozole infusion (A and B) suppressed both GnRH and kisspeptin release within 20 min, whereas vehicle infusion (C and D) did not change release of GnRH and kisspeptin. Note that there was considerable individual variation in elevated GnRH and kisspeptin levels after EB injection.