Table 1.

General parameters from WT and Nat1 KO mice fed either RC or a HFD at 12 wk of age

Parameters	WT	KO
Body weight (RC), g	27.5 ± 0.4	27.6 ± 0.5
Body fat (RC), g	1.7 ± 0.1	2.0 ± 0.2
Body weight (HFD), g	34.2 ± 1.3	36.5 ± 0.9
Body fat (HFD), g	7.9 ± 0.8	9.9 ± 0.8
Fasting insulin (RC), μU/mL	5.4 ± 0.7	6.9 ± 0.8
Clamped insulin (RC), μU/mL	34.9 ± 2.6	35.9 ± 1.8
Fasting Insulin (HFD), μU/mL	14.0 ± 3.3	37.4 ± 8.5*
Clamp insulin (HFD), μU/mL	97.3 ± 5.2	110.5 ± 10.3
Basal NEFA (RC), mmol/L	1.14 ± 0.07	1.12 ± 0.08
Clamp NEFA (RC), mmol/L	0.34 ± 0.03	0.39 ± 0.02
Basal NEFA (HFD), mmol/L	1.18 ± 0.07	1.15 ± 0.05
Clamp NEFA (HFD), mmol/L	0.70 ± 0.05	1.11 ± 0.05**
Plasma TAG (RC), mg/dL	94.5 ± 4.6	99.8 ± 5.9
Plasma TAG (HFD), mg/dL	92.3 ± 3.7	91.1 ± 5.0
Plasma FGF21 (RC), pg/mL	423.2 ± 61.9	540.1 ± 80.8

Data are represented as mean ± SEM (n = 8–10 per group).

^*P < 0.05.

^**P < 0.001 compared with WT mice fed the same diet.