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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Free Radic Biol Med. 2017 Jul 10;114:84–93. doi: 10.1016/j.freeradbiomed.2017.07.009

Figure 1. Trisomy 21-induced oxidative stress.

Figure 1

Schematic representation of a sub set of trisomic genes that are associate dwith increased oxidative stress (OS) conditions. In detail, SOD1, APP and BACH1 are the triplicated genes that are discussed in the review. SOD1 encodes for the enzyme superoxide dismutase; APP fort the amyloid precursor protein; and BACH1 for the transcription repressor BACH1 that bind to the antioxidant response elements (AREs) of DNA thus suppressing the induction of HO-1 and other antioxidant proteins.

CAT=catalase; GPX= glutathione peroxidase; HO-1=heme oxygenase 1; BVR-A= biliverdin reductase A;