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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Free Radic Biol Med. 2017 Jul 10;114:84–93. doi: 10.1016/j.freeradbiomed.2017.07.009

Figure 2. Schematic overview of the main iron metabolic pathways possibly involved in Down Syndrome neurodegeneration.

Figure 2

In blue, proteins found to be altered in Down Syndrome. APP, amyloid precursor protein; BBB, blood brain barrier; CO, carbon monoxide; TFR-1/2, transferrin receptor-1/2;