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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: J Biomed Mater Res A. 2017 Aug 21;105(11):3069–3076. doi: 10.1002/jbm.a.36166

Figure 4. IL-4 triggers pro-osteogenic signals by down-regulating Smurf2 and up-regulating Igf-1.

Figure 4

a) mRNA relative expression were determined from cell lysate by qRT-PCR at day 3 and 6 of direct co-culture; b–c) Day 3 (left panels) and day 6 (right panels) osteogenic related genes (Runx2 and Alpl); d-e) Day 3 (left panels) and day 6 (right panels) NF-kB related genes (Smurf2 and Taz); f) Day 6 Igf-1 and G) Day 6 Vegfa *p<0.05; **p<0.01 and ***p<0.001