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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Trends Immunol. 2017 Sep 14;39(1):55–69. doi: 10.1016/j.it.2017.08.009

Figure 2. lncRNAs in the innate immune system.

Figure 2

(A) LincRNA-Cox2 is induced by TLR ligands and associates with hnRNPA/B and hnRNPA2/B1 to suppress transcription of target genes, such as Ccl5, and promotes the expression of genes such as Il6 through a yet unknown mechanism.

(B) Resting macrophages express high levels lincRNA-EPS, which interacts with hnRNPL to suppress target genes. Upon stimulation, expression of lincRNA-EPS is reduced, and repression of these targets is released.

(C) In short-lived myeloid cells, pro-survival cytokines induce expression of Morrbid, which acts as a guide to target the repressive PRC2 complex to the Bcl2l11 locus (which encodes the pro-apoptotic molecule Bim), to promote the survival of these cells.