Figure 5. Activation of ERK1/2 and HSP27 by exercise-derived extracellular vesicles.
(a) Western blot for ERK1/2 and HSP27 phosphorylation level in H9C2 cells pretreated with EVs or controls (n=3). (b) Western blot for ERK1/2 and HSP27 phosphorylation level in H2O2-treated H9C2 cells with pre-incubation of EVs or controls (n=3). (c) Western blot for ERK1/2 and HSP27 phosphorylation level in I/R hearts pretreated with EVs or PBS (n=3). EVs, extracellular vesicles. *, P<0.05 vs. Control or PBS group; #, P<0.05 vs. Swim group.