Table 5.

Examples of adaptation of cancer therapy and/or inclusion in a cancer surveillance program after diagnosis of a CPS by trio WES

CPS and type of cancer	Adaptation of cancer therapy	Cancer surveillance program according to
Li-Fraumeni syndrome in hypodiploid ALL	Omission of cranial irradiation; instead, administration of additional intrathecal chemotherapy	Kratz et al. Clin Canc Res (2017)
Li-Fraumeni syndrome in plexus carcinoma	Omission of cranial irradiation; instead, high-dose chemotherapy with autologous stem cell transplantation	Kratz et al. Clin Canc Res (2017)
Constitutional mismatch repair deficiency in medulloblastoma	None	Tabori et al. Clin Canc Res (2017)
Dicer syndrome in pleuropulmonary blastoma	None	Schultz et al. Clin Canc Res (2017)
Gorlin syndrome	None	Schultz et al. Clin Canc Res (2017)
Neurofibromatosis type I in glioma	Omission of cranial irradiation; instead, systemic chemotherapy	Evans et al. Clin Canc Res (2017)