Table 1.
Effect of EMD386088, imipramine, s-citalopram, reboxetine, moclobemide, and bupropion given alone or in combination on the rat locomotor activity measured in the OF test
| Treatment | Dose (mg/kg) | Exploratory activity | |||
|---|---|---|---|---|---|
| Total distance (cm) | Rearings | Ambulation X | Ambulation Y | ||
| Vehicle + Vehicle | 0 + 0 | 2790 ± 174 | 72 ± 10 | 291 ± 40 | 275 ± 30 |
| Vehicle + imipramine | 0 + 15 | 2212 ± 332 | 54 ± 3 | 209 ± 37 | 203 ± 41 |
| Vehicle + EMD 386088 | 0 + 2.5 | 2677 ± 232 | 90 ± 3 | 261 ± 29 | 261 ± 31 |
| imipramine + EMD 386088 | 15 + 5 | 1909 ± 125* F(1,20) = 0.4677; p = 0.502 |
89 ± 9 F(1,20) = 1.0969; p = 0.307 |
165 ± 25 F(1,20) = 0.0383; p = 0.847 |
157 ± 30 F(1,20) = 0.2249; p = 0.640 |
| Vehicle + Vehicle | 0 + 0 | 2790 ± 174 | 72 ± 10 | 291 ± 40 | 275 ± 30 |
| Vehicle + s-citalopram | 0 + 10 | 1935 ± 121* | 64 ± 12 | 197 ± 15 | 179 ± 19 |
| Vehicle + EMD 386088 + | 0 + 2.5 | 2677 ± 232 | 90 ± 3 | 261 ± 29 | 261 ± 31 |
| s-citalopram + EMD 386088 | 10 + 2.5 | 2160 ± 173 F(1,20) = 0.8898; p = 0.357 |
69 ± 8 F(1,20) = 0.5108; p = 0.483 |
228 ± 26 F(1,20) = 1.1364; p = 0.299 |
232 ± 27 F(1,20) = 1.5337; p = 0.230 |
| Vehicle + Vehicle | 0 + 0 | 3102 ± 434 | 94 ± 13 | 274 ± 40 | 281 ± 38 |
| Vehicle + reboxetine | 0 + 5 | 2196 ± 74 | 84 ± 6 | 221 ± 16 | 220 ± 12 |
| Vehicle + EMD 386088 + | 0 + 2.5 | 2721 ± 196 | 91 ± 4 | 262 ± 28 | 261 ± 31 |
| reboxetine + EMD 386088 | 5 + 2.5 | 2651 ± 265 F(1,20) = 1.8780; p = 0.186 |
87 ± 6 F(1,20) = 0.0431; p = 0.838 |
267 ± 37 F(1,20) = 0.8117; p = 0.378 |
269 ± 34 F(1,20) = 1.6607; p = 0.212 |
| Vehicle + Vehicle | 0 + 0 | 3102 ± 434 | 94 ± 13 | 274 ± 40 | 281 ± 38 |
| Vehicle + moclobemide | 0 + 10 | 2160 ± 183 | 62 ± 3 | 200 ± 26 | 192 ± 23 |
| Vehicle + EMD 386088 + | 0 + 2.5 | 2644 ± 220 | 89 ± 4 | 262 ± 35 | 267 ± 37 |
| moclobemide + EMD 386088 | 10 + 2.5 | 2405 ± 168, F(1,19) = 1.5830; p = 0.223 |
69 ± 6 F(1,19) = 0.5090; p = 0.484 |
229 ± 25 F(1,19) = 0.4146; p = 0.527 |
244 ± 30 F(1,19) = 1.0302; p = 0.322 |
| Vehicle + Vehicle | 0 + 0 | 2696 ± 308 | 71 ± 7 | 251 ± 31 | 270 ± 40 |
| Vehicle + bupropion | 0 + 10 | 3083 ± 229 | 83 ± 9 | 284 ± 31 | 301 ± 35 |
| Vehicle + EMD 386088 + | 0 + 2.5 | 2722 ± 145 | 92 ± 9 | 263 ± 28 | 262 ± 23 |
| Bupropion + EMD 386088 | 10 + 2.5 | 3284 ± 306 F(1,20) = 0.1094; p = 0.744 |
85 ± 6 F(1,20) = 2.0155; p = 0.171 |
365 ± 47 F(1,20) = 0.9526; p = 0.341 |
334 ± 30 F(1,20) = 0.3473; p = 0.562 |
EMD386088, imipramine, and s-citalopram were injected i.p. 30 min, while reboxetine, moclobemide and bupropion were given i.p. 60 min before the test. Values represent the mean ± SEM during 5-min test session compared to the respective group: vehicle + vehicle group *p < 0.05, NS not significant (two-way ANOVA is followed by the Bonferroni’s post hoc test), N = 6