Table 2.
Pharmacokinetic parameters for EMD386088 administered alone or jointly with imipramine (IMI) in rats
| Parameters | Dose [mg/kg] | ||
|---|---|---|---|
| EMD386088 2.5 | EMD386088 5 | EMD386088 2.5 + IMI 15 | |
| AUC0 → t [ng ⋅ min/mL] | 2210.6 | 4527.4 | 7505.5 |
| t1/2[min] | 67.3 | 64.9 | 77.1 |
| MRT [min] | 78.7 | 78 | 92.8 |
| C max [ng/mL] | 22.9 | 45.2 | 49 |
| t max [min] | 5 | 5 | 60 |
| V d/F [mL/kg] | 102,183.9 | 97,140.3 | 32,204.7 |
| Cl/F [mL/min/kg] | 1052.6 | 1038.8 | 289.4 |
EMD386088 and imipramine were injected i.p.
AUC area under the curve, t 0.5 terminal half-life, C max maximum plasma concentration, t max time to C max, V d /F apparent volume of distribution, Cl/F apparent systemic clearance, MRT mean residence time