Table 3.

Distribution of EMD386088 administered alone or jointly with imipramine (IMI) in rats’ brain

Parameters	Dose [mg/kg]
	EMD386088 2.5	EMD386088 5	EMD38688 2.5 + IMI 15
AUC0 → t [ng ⋅ min/g]	41,936.2	84,462.8	56,428.6
MRT [min]	114	114.8	127.2
C max [ng/g]	321	640.3	276.9
t max [min]	120	120	120

EMD386088 and imipramine were injected i.p.

AUC area under the curve; MRT mean residence time; C _max maximum plasma concentration; t _max time to C _max