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. 2017 Oct 3;74(1):79–89. doi: 10.1007/s00228-017-2344-x

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Goodness-of-fit plots for the final pharmacokinetic model. Panel A illustrates observed (OBS) vs. population predicted (PPRED) treosulfan concentrations and OBS vs. individual predicted (IPRED) treosulfan concentrations with an identity line and smooth. Panel B presents individual-weighted residuals (IWRES) vs. time and PPRED, population-weighted residuals (PWRES) vs. time and PPRED. Panel C presents normalized prediction distribution errors (NPDE) vs. time and PPRED with bold lines as 5th, median and 95th percentile of observed concentrations, light gray area as 50% interval of simulated data and dark gray areas as 95% intervals of simulated data