Table 2.
Final estimates of pharmacokinetic parameters
| Parameter | Final model estimate (%RSE) | Bootstrapped estimate (95% CI) |
|---|---|---|
| Typical value | ||
| Cl [l/h/70 kg] | 14.7 (6.9) | 14.78 (14.70–14.84) |
| βCl, weight | 0.75 (fixed) | 0.75 (fixed) |
| V1 [l/70 kg] | 26.0 (14.0) | 25.94 (25.70–26.18) |
| βV1, weight | 1 (fixed) | 1 (fixed) |
| Q [l/h] | 2.25 (22.2) | 2.63 (2.53–2.72) |
| V2 [l/70 kg] | 9.93 (9.0) | 9.89 (9.74–10.05) |
| βV2, weight | 1 (fixed) | 1 (fixed) |
| IIV [%] | ||
| ωCl | 25.5 (19.8) | 24.0 (23.6–24.3) |
| ωV1 | 51.4 (20.0) | 50.8 (50.2–51.3) |
| ωQ | 38.6 (52.3) | 32.7 (31.6–33.7) |
| ωCl-V1 | 71.4 (20.7) | 68.9 (67.7–70.1) |
| Residual proportional error | 0.188 (9.01) | 0.184 (0.182–0.185) |
RSE relative standard error, CI confidence interval, Cl clearance, V 1 central compartment volume, Q intercompartmental clearance, V 2 peripheral compartment volume, IIV interindividual variability