Table 3.

Biological functions associated with the 29 deregulated miRNAs in OS. (A) IPA biological functionsa and (B) KEGG pathwaysb identified by DIANA miRPath.v3

(A)	P‐value	No. of miRNAs associated
Diseases and disorders
Cancerc	4.14 × 10−13	18
Connective tissue disorders	4.14 × 10−13	12
Organismal injury and abnormalities	4.14 × 10−13	20
Reproductive system disorders	8.23 × 10−9	15
Developmental disorder	4.49 × 10−8	6
Molecular and cellular functions
Cell death and survivalc	2.84 × 10−4	5
Cell‐to‐cell signaling and interactionc	0.00342	1
Cellular developmentc	0.00342	6
Cellular growth and proliferationc	0.00570	6
Cell cyclec	0.0125	1

(B)Pathway	P‐value	No. of miRNAs associated
Proteoglycans in cancerc	2.93 × 10−13	20
Prion diseases	1.52 × 10−10	15
ECM/receptor interactionc	9.02 × 10−10	20
Other types of O‐glycan biosynthesis	6.83 × 10−8	13
Hippo signaling pathwayc	1.49 × 10−7	20
Gliomac	5.18 × 10−6	19
Signaling pathways regulating pluripotency of stem cellsc	5.18 × 10−6	21
Steroid biosynthesis	5.38 × 10−6	9
Mucin‐type O‐glycan biosynthesis	9.70 × 10−6	14
Transcriptional misregulation in cancerc	2.95 × 10−5	21

^a Diseases and molecular functions associated with the 29 deregulated miRNAs identified by IPA.

^b KEGG pathways associated with the 29 deregulated miRNAs identified by DIANA miRPath.v3.

^c Association with cancer development and progression.