Table 4.

Pathways and biological functions associated with genes targeted by deregulated miRNAs

IPA canonical pathways	P‐value
Atherosclerosis signaling	5.60 × 10−7
Role of NANOG in mammalian embryonic stem cell pluripotencya	2.53 × 10−6
Role of osteoblasts, osteoclasts, and chondrocytes in rheumatoid arthritisb	5.59 × 10−6
Role of tissue factor in cancera	1.41 × 10−5
Natural killer cell signalinga	1.53 × 10−5

IPA biological functions	P‐value	No. of genes associated
Diseases and disorders
Connective tissue disorders	2.86 × 10−13	77
Inflammatory disease	2.86 × 10−13	91
Organismal injury and abnormalities	2.86 × 10−13	348
Skeletal and muscular disordersb	2.86 × 10−13	104
Cancera	4.66 × 10−11	343
Molecular and cellular functions
Cellular growth and proliferationa	1.28 × 10−11	121
Cellular movementa	1.70 × 10−10	80
Cellular Developmenta	1.05 × 10−9	86
Cell‐to‐cell signaling and interactiona	5.07 × 10−8	60
Cell death and survivala	6.10 × 10−7	102

KEGG pathways		No. of genes associated
Metabolic pathwaysa		22
MAPK signaling pathwaya		17
Pathways in cancera		16
Cytokine/cytokine receptor interactiona		14
PI3K‐Akt signaling pathwaya		14
Ras signaling pathwaya		14
Proteoglycans in cancera		13
Regulation of actin cytoskeletona		12
Rap1 signaling pathway		12
MicroRNAs in cancera		11

IPA and KEGG analysis of the 301 upregulated and 60 downregulated genes identified to be targeted by the 29 deregulated miRNAs.

^a Association with cancer development and progression.

^b Association with bone cell biology.