TABLE 1.
Characteristics of the study participants according to MTNR1B rs10830963 genotypes
| CC (n = 393) | CG (n = 273) | GG (n = 56) | P | |
| Age (years) | 50.8 (9.2) | 51.0 (9.1) | 53.0 (10.3) | 0.24 |
| Sex | 0.72 | |||
| Male | 149 (37.9) | 112 (41.0) | 22 (39.3) | |
| Female | 244 (62.1) | 161 (59.0) | 34 (60.7) | |
| Race or ethnic group | <0.001 | |||
| White | 279 (71.0) | 247 (90.5) | 49 (87.5) | |
| Black | 96 (24.4) | 12 (4.4) | 3 (5.4) | |
| Hispanic or other | 18 (4.6) | 14 (5.1) | 4 (7.1) | |
| Diet group | 0.69 | |||
| Low fat | 198 (50.4) | 134 (49.1) | 31 (55.4) | |
| High fat | 195 (49.6) | 139 (50.2) | 25 (44.6) | |
| TG, (mg/dl) | 137.4 (86.8) | 151.4 (85.4) | 151.5 (84.4) | 0.09 |
| Total cholesterol (mg/dl) | 200.0 (37.3) | 204.4 (37.2) | 206.2 (33.9) | 0.22 |
| LDL cholesterol (mg/dl) | 125.0 (32.0) | 125.9 (32.7) | 126.4 (31.2) | 0.92 |
| HDL cholesterol (mg/dl) | 48.2 (13.3) | 48.9 (13.8) | 51.2 (20.3) | 0.31 |
| Body weight (kg) | 93.7 (15.0) | 92.8 (16.0) | 92.0 (17.5) | 0.66 |
| Body weight loss at 2 years (kg) | −3.7 (0.4) | −4.1 (0.5) | −6.0 (1.0) | 0.13a |
| BMI (kg/m2) | 32.9 (3.8) | 32.3 (3.9) | 32.5 (3.7) | 0.11 |
| BMI loss at 2 years (kg/m2) | −1.3 (0.1) | −1.4 (0.2) | −2.1 (0.3) | 0.12a |
Data were calculated by the χ2 test for categorical variables and ANOVA for continuous variables. Data are expressed as n (%) or mean (SD).
a
Adjusted for age, sex, ethnicity, baseline value for the respective outcome, and diet group.