Table 2.
Cutoff values, p values, specificity and sensitivity of every antigen in the multiplex H. pylori assay.
| p Values | |||||||
|---|---|---|---|---|---|---|---|
| Antigen | Cutoff (MFI) | Negative vs. Positive | Negative vs. Eradicated | Positive vs. Eradicated | Specificity (%) | Sensitivity (%) | |
| infection status | FliD | 0.20 | 5.72 × 10−29 | 4.80 × 10−14 | 5.84 × 10−14 | 96.8 | 95.7 |
| gGT | 0.95 | 4.73 × 10−23 | 1.69 × 10−10 | 3.39 × 10−10 | 95.2 | 82.0 | |
| GroEL | 2.76 | 2.02 × 10−24 | 3.58 × 10−7 | 5.99 × 10−17 | 96.8 | 87.1 | |
| HpaA | 0.66 | 3.16 × 10−25 | 1.32 × 10−10 | 2.32 × 10−12 | 97.4 | 84.2 | |
| HP lysate | 1.08 | 2.42 × 10−30 | 5.02 × 10−18 | 1.04 × 10−20 | 100.0 | 99.3 | |
| stratification | CagA | 3.80 | 1.69 × 10−16 | 9.84 × 10−15 | 2.30 × 10−4 | 95.2 | 70.5 |
| VacA m1 | 5.66 | 1.15 × 10−9 | 4.13 × 10−2 | 2.11 × 10−4 | 100.0 | 21.6 | |
| HP0231 | 2.86 | 2.21 × 10−11 | 1.39 × 10−2 | 2.69 × 10−6 | 98.4 | 84.2 | |
For the significance testing between the investigated patient groups, a Mann–Whitney U Test was used. Except for two values, all p values are below the Bonferroni corrected significance level α′ = 0.01 ÷ 8 antigens = 1.25 × 10−3.