Table 2.
Conservation of kinase and phosphatase amino acid sequences from sea urchin to human.
| Enzyme Name | Percent Identity | Percent Similarity |
|---|---|---|
| Protein kinase C | 68.4 | 80 |
| PKC conserved region 1 (phorbol ester binding site) | 90 | 92 |
| Serine/threonine catalytic domain | 81.1 | 92.7 |
| cAMP-dependent protein kinase catalytic subunit αisoform | 78.7 | 89.8 |
| Casein kinase 2 α subunit | 79.1 | 86.9 |
| Abl-related protein tyrosine kinase | 69.1 | 80.6 |
| Src-family protein tyrosine kinase | 54.4 | 67.9 |
| Rho kinase | 47.2 | 64.4 |
| Rho kinase associated coiled coil (containing PH domain) | 55.4 | 69.6 |
| Calmodulin-dependent protein kinase 1 | 57.6 | 76.6 |
| Calmodulin-dependent protein kinase kinase | 33.4 | 44.3 |
| Protein phosphatase 2A catalytic subunit | 94.4 | 97.4 |
| Calcineurin B homologous protein | 62.2 | 74.0 |
| Diacylglycerol kinase | 52.8 | 65.8 |
| Ceramide kinase | 44.8 | 66.5 |
| Sphingosine kinase | 43.3 | 61.0 |
| Sphingosine kinase conserved domains: | ||
| C 1 | 64.7 | 76.5 |
| C 2 | 40.0 | 72.0 |
| C 3 | 75.0 | 91.7 |
| C 4 | 57.1 | 82.1 |
| C 5 | 80.0 | 100.0 |