Figure 3.

Integrative scheme of studies focusing on respiratory virus infections. All three actors of the viral disease need to first be completely characterized (microbiome characterization for the environment, viral genome to study the pathogen itself and transcriptomic analyses for the host response). These interactions between host, its microbiome and the pathogen are very important in viral infections pathogeneses. After a complete characterization of these parameters, mechanistic understanding, using animal models, is needed before using these data in clinical diagnosis optimization or for the development of new therapies.