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. 2017 Dec 9;5(4):49. doi: 10.3390/vaccines5040049

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Immunization with B. pseudomallei OMVs provides protection against glanders disease in nonhuman primates. Pulmonary function of rhesus macaques vaccinated with OMV or saline (sham-vaccinated). (a) Relative change (Δ) in tidal volume (mL/breath) prior to challenge when compared to measurement +7 days after B. mallei aerosol challenge. Group comparison by Kolmogorov-Smirnov test, significance at * p < 0.05; (b) Spleen weight over total body weight was calculated as a percentage to quantify degree of splenomegaly (* p < 0.05).