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. 2017 Nov 20;10(4):87. doi: 10.3390/ph10040087

Scheme 2.

Scheme 2

Synthesis of 4-(4-bromoanilino)-6-(4-fluorophenyl)quinazoline derivatives 4e and 4k. Reagents & conditions: (i) 4-FC6H4B(OH)2, PdCl2(PPh3)2, K2CO3, dioxane (aq), reflux, 3 h; (ii) POCl3, Et3N, reflux, 5 h; (iii) 4-NH2C6H4Br, HCl, THF-iPrOH, 70 °C, 3 h.