| Activity of TMZ, compounds 1 and 2 against a panel of TMZ susceptible and resistant cell lines | |||
| Compound | GI50 Value ± SD (µM) | ||
| U373 V | U373 M | HCT 116 | |
| TMZ | 51.9 ± 7.4 | 302 ± 56 | 291 ± 4.9 |
| 1 | 61.0 ± 6.0 | >500 | 233 ± 80 |
| 2 | 36.1 ± 2.9 | 29.1 ± 2.5 | 32.3 ± 10 |
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