Table 2.

Selected zebrafish models of potential interest for the biological evaluation of genetic nanomedicines.

Model	Features	Application	Ref
Wild type	From nature, with pigmentation according to sex, without fluorescence	Toxicity, biodistribution, xenograft	[194]
Flk-1:eGFP	Fluorescent vascular system	Toxicity, biodistribution, xenograft, angiogenesis, extravasation, half-life circulation, metastasis	[107,130]
Fli-1:eGFP			[107,127,162]
Gata1:DsRed			[107]
Nacre/fli1:eGFP			[163]
Casper fli	Without pigmentation (transparent) and fluorescent vascular system		[91]
Casper	Without pigmentation (transparent)	Toxicity, biodistribution, xenograft, metastasis	[91]
ARE:eGFP	Fluorescence of reactive oxygen species (ROS)	Toxicity	[162]
Cmlc2:eGFP	Fluorescence in the heart	Cardiotoxicity	[167]
Mpo:GFP	Fluorescent neutrophils	Interaction, half-life circulation, immuno response	[167]
Mpeg1:mcherry	Fluorescent macrophages		[127]
Hsp70:eGFP	Fluorescence of the protein HSP70 stress product	Toxicity	[195]