Table 1.
Tests for positive selection among codons of SmSABATH genes using site models.
Model | np | lnL | Estimates of Parameter 1 | 2ΔlnL | Positive Selection Sites 2 | |
---|---|---|---|---|---|---|
Frequency | dN/dS | |||||
M0 (one-ratio) | 60 | −24,100.940606 | 0.32227 | None | ||
M3 (discrete) | 64 | −23,631.868500 |
p0 = 0.15469 p1 = 0.41191 p2 = 0.43340 |
ω0 = 0.06316 ω1 = 0.25310 ω2 = 0.65803 |
938.1442 (M3 vs. M0) ** | Not allowed |
M1a (nearly neutral) | 61 | −23,766.855086 |
p0 = 0.53255 p1 = 0.46745 |
ω0 = 0.23043 ω1 = 1.00000 |
None | |
M2a (positive selection) | 63 | −23,766.855086 |
p0 = 0.53255 p1 = 0.30714 p2 = 0.16031 |
ω0 = 0.23043 ω1 = 1.00000 ω2 = 1.00000 |
0 (M2a vs. M1a) | Not allowed |
M7 (beta) | 61 | −23,622.773935 |
p = 1.10441 q = 1.67064 |
None | ||
M8 (beta & ω) | 63 | −23,622.775486 |
p0 = 0.99999 p = 1.10448 q = 1.67080 p1 = 0.00001 |
ω = 5.70606 | 0.00308 (M8 vs. M7) | 181 Q 432 V 434 G 460 S 476 H 479 C |
Note: * p < 0.05 and ** p < 0.01 (x2 test). 1 ω was estimated under models; p and q were the parameters of the beta distribution. 2 The number of amino acid sites estimated to have undergone positive selection. np was the number of parameter. lnL was the values of log-likelihood. dN/dS was non-synonymous/synonymous. 2ΔlnL was the value of twice the log likelihood difference between models.