Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Dec 12;8(12):383. doi: 10.3390/genes8120383

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

DEmiRs affecting CD4⁺ T cell development. Hypothetical network of DEmiRs affecting T helper (Th) cell maturation. Downregulated miR-128 is known to promote Th cell development towards the Th2 side while negatively regulating Th1 cell maturation. Additionally, IL6 production is increased by downregulated miR-128 while TGFβ production is enhanced by downregulated miR-744. We hypothesize that this leads to an increased Th2/Th17 immune response upon antigen challenge rendering certain horses susceptible to develop severe equine asthma. This hypothesis is supported by a previous finding of downregulated interferon gamma (IFNG) and upregulated C-X-C motif chemokine ligand 13 (CXCL13) in PBMCs of the same affected horses.