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. 2017 Dec 6;9(12):1328. doi: 10.3390/nu9121328

Figure 2.

Figure 2

Flavanone metabolites reduce stearate-induced inflammation in MACs. Pro-inflammatory marker (IL-1β, IL-6, IL-8 and TNF-α) gene expression in MACs pre-incubated with 1 µM of naringenin-7-O-glucuronide (N7G), naringenin-4′-O-glucuronide (N4G), hesperetin-7-O-glucuronide (H7G) and hesperetin-3′-O-glucuronide (H3G) for 16 h and then exposed to stearate (SA, 100 µM) for 3 h is shown. Vehicle (DMSO 0.1%) was used as control (untreated). Real time PCR data are normalized to GAPDH housekeeping gene and expressed as fold induction of SA culture condition. The results represent means ± SEM (* p < 0.05 vs. stearate; ** p < 0.01 vs. stearate; n = 8).