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. 2017 Dec 7;9(12):1332. doi: 10.3390/nu9121332

Table 3.

Data from the Cognitive Demand Battery tasks that were repeated four times during each assessment.

Pre-Dose Baseline 40 min Post-Dose (Change) 60 min Post-Dose (Change) ANOVA Sig. Effects
Day Rep 1 Rep 2 Rep 3 Rep 4 Rep 1 Rep 2 Rep 3 Rep 4 Rep 1 Rep 2 Rep 3 Rep 4
RVIP % correct Day 1 Plac 63.33 3.34 60.1 3.34 57.92 3.41 55.5 3.65 −4.31 1.92 −3.82 1.81 −3.33 1.77 −2.50 2.38 −4.44 1.95 −5.76 1.96 −5.63 2.12 0.35 2.08 Treatment p < 0.001
Nut+ 60.18 3.13 58.7 3.13 56.10 3.20 52.8 3.42 3.35 1.80 5.30 1.70 6.28 1.66 7.44 2.23 4.27 1.82 −0.55 1.84 0.73 1.98 3.90 1.95
Day 56 Plac 59.17 3.28 54.4 3.38 54.31 3.63 51.1 3.36 −7.08 2.11 −2.22 1.91 −7.36 2.04 −2.01 2.24 −6.67 1.92 −4.83 2.13 −3.82 1.99 −3.54 2.44
Nut+ 55.49 3.08 51.6 3.17 50.37 3.41 49.1 3.15 6.77 1.98 4.15 1.79 3.96 1.92 8.05 2.09 3.41 1.80 6.83 1.99 5.49 1.87 6.16 2.28
RVIP Reaction time msec Day 1 Plac 489.54 8.75 489 8.32 490 8.89 495 7.99 −3.07 6.22 −8.94 5.83 −11.7 6.74 −7.21 6.20 −9.49 6.44 −17.8 5.64 −12.8 6.46 −9.38 7.15 Treatment p < 0.006
Nut+ 486.76 8.20 483 7.80 483 8.33 483 7.49 −16.2 5.83 −18.3 5.46 −12.7 6.32 −7.7 5.81 −20.8 6.04 −17.8 5.29 −13.5 6.06 −8.32 6.70
Day 56 Plac 486.55 7.84 486 8.48 491 8.37 495 7.65 0.05 5.36 −1.91 5.48 3.20 6.35 −8.26 6.65 −10.3 5.94 −6.47 5.22 −3.93 6.70 −17.4 7.14
Nut+ 488.00 7.34 497 7.95 502 7.84 493 7.17 −13.3 5.02 −23.5 5.14 −28.3 5.95 −14.6 6.23 −19.5 5.57 −29.6 4.89 −19.6 6.27 −17.9 6.69
RVIP False alarms Day 1 Plac 0.81 0.16 0.81 0.15 0.92 0.18 0.78 0.14 −0.08 0.16 0.10 0.20 −0.08 0.18 −0.08 0.16 −0.06 0.18 0.00 0.19 −0.28 0.21 −0.19 0.18 Treatment p < 0.005
Nut+ 0.42 0.15 0.46 0.14 0.34 0.17 0.34 0.13 0.24 0.15 0.15 0.19 0.02 0.17 0.27 0.15 0.17 0.17 0.37 0.18 0.37 0.20 0.49 0.17
Day 56 Plac 0.92 0.18 0.83 0.14 0.78 0.15 0.69 0.14 −0.03 0.21 −0.08 0.19 −0.08 0.24 −0.14 0.20 −0.28 0.21 −0.28 0.15 −0.14 0.18 0.22 0.18
Nut+ 0.73 0.17 0.56 0.13 0.56 0.14 0.59 0.13 −0.12 0.20 0.07 0.17 0.27 0.22 0.15 0.18 −0.05 0.20 0.00 0.14 0.07 0.16 −0.05 0.17
Serial 3s Number correct Day 1 Plac 44.60 2.17 46.42 2.20 45.69 2.03 44.90 2.18 4.71 1.00 1.46 1.04 1.60 1.07 3.06 1.09 3.60 1.10 1.46 1.04 3.15 1.30 1.52 1.25 Treatment p < 0.001
Nut+ 46.68 2.20 49.30 2.22 47.77 2.05 48.70 2.20 7.60 1.01 3.94 1.05 5.28 1.08 5.02 1.10 7.09 1.11 4.45 1.05 4.36 1.31 4.34 1.26
Day 56 Plac 43.48 2.40 47.65 2.28 45.73 2.30 45.58 2.36 6.48 1.52 2.06 1.27 3.33 1.11 −0.79 1.38 7.90 1.64 1.81 1.16 3.15 1.40 2.46 1.31
Nut+ 45.75 2.42 48.11 2.31 48.49 2.32 48.38 2.39 9.85 1.54 7.74 1.28 6.15 1.12 5.13 1.39 11.30 1.66 5.26 1.17 5.81 1.41 6.28 1.32
Serial 3s Number of errors Day 1 Plac 2.15 0.30 2.06 0.37 2.42 0.33 2.50 0.38 0.73 0.44 0.63 0.46 0.02 0.42 0.00 0.40 0.42 0.37 0.69 0.38 0.19 0.39 0.29 0.49
Nut+ 2.77 0.30 2.64 0.38 2.72 0.33 2.72 0.39 0.00 0.45 0.15 0.46 0.11 0.42 0.28 0.41 −0.13 0.37 −0.26 0.38 −0.68 0.40 −0.11 0.50
Day 56 Plac 2.96 0.37 2.46 0.35 2.67 0.36 2.56 0.35 0.63 0.47 0.19 0.37 −0.17 0.46 0.58 0.47 −0.06 0.47 −0.17 0.39 −0.33 0.39 −0.19 0.43
Nut+ 2.30 0.37 2.45 0.35 2.36 0.36 2.57 0.35 0.94 0.47 −0.30 0.38 0.55 0.47 0.40 0.48 0.49 0.47 0.38 0.39 −0.02 0.40 −0.15 0.44
Serial 7s number correct Day 1 Plac 25.94 1.51 26.42 1.52 26.81 1.58 26.40 1.53 2.83 0.75 2.38 0.79 1.56 0.84 1.58 0.79 2.50 0.79 2.90 0.88 3.17 0.88 3.92 0.81 Treatment p < 0.001
Nut+ 28.00 1.53 28.43 1.53 29.40 1.60 29.64 1.55 4.68 0.76 4.00 0.80 4.21 0.85 4.06 0.80 5.87 0.80 4.40 0.89 3.49 0.89 3.83 0.82
Day 56 Plac 26.58 1.48 26.17 1.57 26.98 1.50 27.15 1.61 2.25 0.88 2.52 0.91 1.21 0.91 1.13 1.06 4.33 0.97 4.10 1.09 2.92 0.90 2.54 0.95
Nut+ 27.96 1.50 29.53 1.59 29.92 1.52 28.51 1.62 5.21 0.89 3.62 0.92 3.11 0.91 4.68 1.07 7.23 0.98 4.89 1.10 3.79 0.91 5.30 0.96
Serial 7s number of errors Day 1 Plac 2.25 0.34 2.33 0.34 2.71 0.35 2.31 0.37 0.94 0.44 0.10 0.43 0.38 0.42 0.69 0.46 0.75 0.36 0.60 0.42 −0.17 0.43 0.50 0.42
Nut+ 2.26 0.35 2.81 0.35 2.89 0.35 3.21 0.38 0.70 0.45 0.68 0.44 0.23 0.43 −0.26 0.46 0.32 0.36 −0.32 0.43 0.38 0.44 0.17 0.42
Day 56 Plac 2.44 0.32 2.69 0.34 2.50 0.30 2.83 0.40 0.88 0.35 −0.10 0.41 0.83 0.40 0.15 0.40 0.31 0.35 −0.27 0.39 0.58 0.35 0.23 0.41
Nut+ 2.32 0.32 2.62 0.34 2.92 0.30 3.75 0.41 0.79 0.35 0.04 0.41 0.09 0.41 −0.53 0.41 0.38 0.36 0.53 0.39 0.02 0.35 −0.87 0.41
Fatigue % along VAS Day 1 Plac 56.29 2.48 59.35 2.80 62.29 2.84 65.08 2.93 3.81 2.42 6.58 2.27 5.19 2.36 3.90 2.16 8.40 2.43 10.48 2.22 10.04 2.14 7.10 1.90 Treatment p < 0.001
Nut+ 57.89 2.51 62.83 2.83 67.38 2.87 70.45 2.96 −5.60 2.44 −7.09 2.30 −8.96 2.39 −11.5 2.18 −1.43 2.45 0.79 2.24 0.94 2.16 −0.28 1.92
Day 56 Plac 51.88 2.51 58.73 2.46 63.31 2.55 66.25 2.72 8.10 2.40 6.19 2.19 4.79 2.05 3.85 1.97 10.67 2.47 9.71 2.31 5.15 2.39 3.90 2.27
Nut+ 57.87 2.53 65.45 2.49 70.47 2.57 74.87 2.75 −0.98 2.42 −3.40 2.21 −4.53 2.07 −6.28 1.99 5.17 2.50 3.49 2.34 1.53 2.41 −1.28 2.30

Data are means (±SEM, in italics) and comprise raw data from the pre-dose baseline assessment and “change from baseline” (adjusted to the days’ corresponding pre-dose score) data for the 40 min and 160 min post-dose assessments. Sample sizes were 77 (placebo 36) for the Rapid Visual Information Processing task (RVIP) and 95 (placebo 48) for the Serial 3s, 7s and fatigue. Treatment = main effect of treatment from the ANOVA; Plac = placebo; Nut+ = nutrient enriched; RVIP = Rapid Visual Information Processing task; Rep = repetition of task.