Table 1.
Distribution of unmetabolized resveratrol in plasma (nmol/mL), various organs (nmol/g of tissue), urine (nmol/mL), and feces (nmol/g wet content) of mice at different time-points following the intragastric administration of a single dose of 10 mg/kg resveratrol. Maximum concentrations (Cmax values) are in bold.
| Sample | Resveratrol Concentration | ||||||
|---|---|---|---|---|---|---|---|
| 0.5 h | 1 h | 1.5 h | 2 h | 4 h | 6 h | 8 h | |
| Plasma | 0.140 ± 0.012 | 0.132 ± 0.017 | 0.118 ± 0.017 | 0.124 ± 0.041 | 0.135 ± 0.036 | 0.220 ± 0.079 | 0.152 ± 0.023 |
| Spleen | 4.347 ± 3.686 | 3.434 ± 1.946 | 3.305 ± 3.473 | 7.232 ± 1.050 | 3.218 ± 2.983 | 3.134 ± 1.824 | 2.229 ± 2.045 |
| Liver | 0.439 ± 0.133 | 0.358 ± 0.255 | 0.424 ± 0.217 | 0.345 ± 0.252 | 0.281 ± 0.105 | 0.141 ± 0.023 | 0.128 ± 0.033 |
| Kidney | 0.740 ± 0.361 | 0.786 ± 0.441 | 0.881 ± 0.436 | 0.418 ± 0.365 | 0.548 ± 0.140 | 0.667 ± 0.039 | 0.602 ± 0.137 |
| Heart | 3.698 ± 2.519 | 1.097 ± 1.094 | 1.176 ± 1.091 | 1.169 ± 1.126 | 1.129 ± 0.978 | 0.931 ± 0.339 | 0.276 ± 0.147 |
| Lung | 3.505 ± 2.985 | 1.791 ± 0.699 | 1.968 ± 1.769 | 1.899 ± 2.056 | 0.857 ± 0.749 | 2.388 ± 1.989 | 1.827 ± 1.300 |
| Stomach | 128.9 ± 74.38 | 111.8 ± 52.42 | 71.18 ± 60.49 | 40.93 ± 35.12 | 5.065 ± 2.220 | 1.709 ± 1.490 | 2.600 ± 1.072 |
| Duodenum | 10.01 ± 4.763 | 4.505 ± 2.787 | 6.551 ± 4.581 | 0.984 ± 0.081 | 0.752 ± 0.210 | 1.651 ± 0.673 | 1.100 ± 0.452 |
| Jejunum | 3.590 ± 1.692 | 1.693 ± 0.854 | 2.386 ± 2.288 | 0.889 ± 0.261 | 0.485 ± 0.133 | 0.715 ± 0.044 | 0.985 ± 0.515 |
| Ileum | 8.435 ± 2.611 | 26.17 ± 19.12 | 6.411 ± 2.166 | 2.074 ± 1.421 | 1.513 ± 0.512 | 1.289 ± 1.120 | 2.428 ± 1.751 |
| Cecum | 22.66 ± 15.47 | 11.52 ± 4.843 | 163.5 ± 138.5 | 30.72 ± 16.22 | 29.05 ± 19.92 | 1.761 ± 1.569 | 2.587 ± 2.235 |
| Colon | 7.422 ± 2.339 | 2.292 ± 1.390 | 22.04 ± 10.64 | 10.34 ± 6.731 | 9.754 ± 5.745 | 0.862 ± 1.087 | 2.655 ± 0.496 |
| Thymus | 15.01 ± 8.971 | 15.21 ± 6.934 | 4.784 ± 1.286 | 2.857 ± 0.192 | 0.818 ± 0.314 | 2.351 ± 1.051 | 11.01 ± 4.994 |
| Muscle | 1.530 ± 0.824 | 0.680 ± 0.619 | 0.557 ± 0.489 | 0.695 ± 1.203 | 0.555 ± 0.483 | 0.163 ± 0.128 | 0.333 ± 0.177 |
| Brain | 0.484 ± 0.337 | 0.212 ± 0.167 | 0.127 ± 0.054 | 0.041 ± 0.014 | ND | ND | ND |
| Urine | 4.716 ± 0.057 | 3.510 ± 0.513 | 15.70 ± 11.85 | 0.779 ± 0.106 | 5.091 ± 3.238 | 5.455 ± 2.562 | 4.472 ± 2.398 |
| Feces | 49.62 ± 29.79 | 186.5 ± 135.1 | 171.8 ± 79.23 | 292.5 ± 156.6 | 336.9 ± 219.2 | 22.24 ± 14.37 | 15.58 ± 13.93 |
Data are expressed as the mean ± SD; n = 3. ND: not detected.