Table 4.

Distribution of resveratrol-3-O-4′-O-disulfate in plasma (nmol/mL), various organs (nmol/g of tissue), urine (nmol/mL), and feces (nmol/g wet content) in mice at different time-points following the intragastric administration of resveratrol at a single dose of 10 mg/kg. Maximum concentrations (C_max values) are in bold.

Sample	Resveratrol-3-O-4′-O-Disulfate Concentration
	0.5 h	1 h	1.5 h	2 h	4 h	6 h	8 h
Plasma	0.099 ± 0.016	0.090 ± 0.028	0.039 ± 0.023	0.050 ± 0.044	0.033 ± 0.022	0.042 ± 0.037	0.049 ± 0.033
Spleen	ND	ND	ND	ND	ND	ND	ND
Liver	0.585 ± 0.258	0.267 ± 0.143	0.422 ± 0.100	0.517 ± 0.073	0.218 ± 0.036	0.019 ± 0.032	0.021 ± 0.037
Kidney	0.430 ± 0.252	0.692 ± 0.516	0.387 ± 0.113	0.986 ± 0.720	0.767 ± 0.101	0.247 ± 0.182	0.078 ± 0.046
Heart	0.406 ± 0.203	0.973 ± 0.332	ND	ND	ND	ND	ND
Lung	0.673 ± 0.867	0.275 ± 0.177	0.164 ± 0.102	0.438 ± 0.258	ND	ND	ND
Stomach	15.08 ± 9.413	4.088 ± 3.812	4.899 ± 3.492	1.448 ± 0.834	1.389 ± 0.556	0.251 ± 0.234	0.350 ± 0.076
Duodenum	12.54 ± 6.672	5.273 ± 4.943	5.080 ± 3.785	1.092 ± 0.104	0.956 ± 0.306	0.203 ± 0.176	0.123 ± 0.113
Jejunum	1.666 ± 1.280	1.210 ± 0.841	1.233 ± 1.175	0.665 ± 0.191	0.527 ± 0.315	0.166 ± 0.098	ND
Ileum	2.264 ± 0.441	2.594 ± 0.577	2.749 ± 1.006	1.474 ± 0.938	1.219 ± 0.518	0.260 ± 0.150	0.270 ± 0.168
Cecum	0.363 ± 0.319	0.280 ± 0.485	0.807 ± 0.706	1.123 ± 0.991	0.305 ± 0.328	ND	ND
Colon	0.751 ± 0.287	0.377 ± 0.136	0.843 ± 0.505	0.632 ± 0.433	ND	ND	ND
Thymus	ND	ND	ND	ND	ND	ND	ND
Muscle	0.167 ± 0.089	0.327 ± 0.167	0.255 ± 0.214	ND	ND	ND	ND
Brain	ND	ND	ND	ND	ND	ND	ND
Urine	7.382 ± 0.362	53.17 ± 23.97	10.19 ± 3.056	50.06 ± 24.88	67.57 ± 33.96	106.0 ± 48.06	58.26 ± 23.76
Feces	11.92 ± 2.654	6.930 ± 2.455	1.767 ± 0.060	1.821 ± 0.155	1.989 ± 0.446	7.778 ± 3.473	3.155 ± 5.465

Data are expressed as the mean ± SD; n = 3. ND: not detected.