Table 5.
Area under the concentration–time curves (AUCs) (0–8 h) for plasma, urine, feces, or tissues of resveratrol (Res), resveratrol-3-O-glucuronide (Res3G), resveratrol-3-O-sulfate (Res3S), and resveratrol-3-O-4′-O-disulfate (ResDiS) in mice that received resveratrol (10 mg/kg) intragastrically.
| Sample | AUC (nmol/mL min or nmol/g min) | ||||||
|---|---|---|---|---|---|---|---|
| Res | Res3G | Res3S | ResDiS | AUCRes/AUCRes3G | AUCRes/AUCRes3S | AUCRes/AUCResDiS | |
| Plasma | 1.21 ± 0.72 | 0.59 ± 0.22 | 0.71 ± 0.28 | 0.37 ± 0.15 | 2.05 | 1.70 | 3.27 |
| Spleen | 27.8 ± 4.35 | 2.23 ± 1.91 | 0.28 ± 0.16 | n.a. | 12.5 | 99.7 | n.a. |
| Liver | 2.02 ± 0.44 | 4.12 ± 2.17 | 4.59 ± 1.65 | 1.78 ± 0.56 | 0.50 | 0.44 | 1.13 |
| Kidney | 4.76 ± 0.88 | 6.92 ± 2.67 | 5.56 ± 1.60 | 3.60 ± 0.99 | 0.69 | 0.86 | 1.32 |
| Heart | 8.84 ± 3.70 | 2.00 ± 1.16 | 1.99 ± 1.41 | 0.83± 0.37 | 4.41 | 4.45 | 10.6 |
| Lung | 14.3 ± 3.51 | 8.27 ± 3.44 | 6.92 ± 2.88 | 1.02 ± 0.67 | 1.73 | 2.07 | 14.0 |
| Stomach | 223 ± 118 | 84.3 ± 32.7 | 116 ± 46.2 | 17.5 ± 5.08 | 2.65 | 1.92 | 12.8 |
| Duodenum | 17.7 ± 10.1 | 53.8 ± 26.0 | 96.9 ± 37.3 | 15.3 ± 6.54 | 0.33 | 0.18 | 1.16 |
| Jejunum | 8.33 ± 3.59 | 18.8 ± 11.3 | 33.0 ± 16.1 | 4.27 ± 1.67 | 0.44 | 0.25 | 1.95 |
| Ileum | 31.1 ± 16.2 | 92.1 ± 38.6 | 182 ± 98.2 | 8.43 ± 3.96 | 0.34 | 0.17 | 0.62 |
| Cecum | 201 ± 63.5 | 5.39 ± 3.17 | 44.9 ± 24.9 | 2.74 ± 1.12 | 37.4 | 4.48 | 73.5 |
| Colon | 52.7 ± 22.0 | 9.87 ± 4.39 | 14.3 ± 6.12 | 1.21 ± 0.84 | 5.34 | 3.68 | 43.5 |
| Thymus | 34.9 ± 12.7 | 6.19 ± 2.26 | 14.2 ± 8.35 | n.a. | 5.63 | 2.46 | 0.0 |
| Muscle | 4.02 ± 1.53 | 2.37 ± 0.68 | 0.76 ± 0.21 | 0.74 ± 0.17 | 1.70 | 5.31 | 5.45 |
| Brain | 0.46 ± 0.18 | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. |
| Urine | 38.8 ± 13.6 | 1521 ± 411 | 462 ± 103 | 503 ± 141 | 0.03 | 0.08 | 0.08 |
| Feces | 1304 ± 337 | 24.1 ± 12.6 | 156 ± 52.6 | 35.3 ± 11.9 | 54.1 | 8.36 | 37.0 |
Data are expressed as mean ± SD; n = 3. n.a.: not applicable.