Table 1.

Summary of the echocardiographic parameters for patient selection and response prediction. RV: right ventricle, IVMD: interventricular mechanical delay, LV: left ventricle, LVPEP: left ventricular pre-ejection period, RVPEP: right ventricular pre-ejection period, PW: pulsed wave, LVOT: left ventricular outflow tract, RVOT: right ventricular outflow tract, TDI: tissue doppler imaging, PLAX: parasternal long-axis view.

Parameter	Description	View	Cutt-off	Advantages	Disadvantages
Apical rocking	Visual assessment of apical transverse motion	Apical 4-chamber view	Yes/No	Highly reproducible method, high specificity for response prediction	Affected by RV function
Septal flash	Visual assessment of short inward septal motion during beginning of systole	Apical 4-chamber view	Yes/No	Highly reproducible method, high specificity for response prediction	Translation of continuous process to on/off phenomenon, observer differences
IVMD	Interventricular mechanical delay, difference in onset of outflow of LV (LVPEP) and RV (RVPEP)	PW Doppler of LVOT and RVOT	40 msec	Highly reproducible method	Affected by both LV and RV function
Septal strain patterns	Strain pattern of the septum during systole	Apical 4-chamber view	3 types (1,2 responder/ 3 non-responder)	Prediction of volumetric response and outcome	Technically demanding
SD-TTP	Standard deviation of time to peak shortening (strain) or velocity (TDI) of all myocardial segments	Apical 4-chamber view, 2-chamber view, PLAX view	> 32 msec	Offline analysis	Requires high quality image, confounded by passive motion tethering
SL delay	Difference of time to peak velocity of septal and lateral view	Apical 4-chamber view	> 65 msec	Prediction of volumetric response and outcome	Confounded by passive motion tethering
SDI	Time to minimal systolic volume of 16 segments	3D	9.8%	High value for response prediction	Limited spatial and temporal resolution
SRSsept (Systolic rebound stretch of the septum)	All positive deflections after initial shortening of the septum during systole	Apical 4-chamber view	4.7%	Prediction of volumetric response and outcome	Technically demanding, observer differences