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. 2017 Dec 22;11:84–91. doi: 10.2174/1874205X01711010084

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© 2017 Boumil et al.

This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig. (1) — Ω-6 delayed motor neuron decline.

Mice maintained on the indicated diets commencing at 4 weeks of age were subjected to motor function assays at the indicated ages. The 1000xΩ-3,6 diet (Yip et al., 2013) hastened, while the 10xΩ-6 diet delayed, the 50% Survival point (panel C; p<0.05 for both, ANOVA asterisks) as compared to the standard diet (with no supplementation with either Ω). The 10xΩ-6 diet significantly (p<0.05; Student’s t tests; asterisks) sustained motor function for 1-1.5 weeks longer than the 4xΩ-3,6 as assayed by Motor Deficit (panel B), Quadrant test (panel C, trend lines calculated via Excel) and overall Activity (panel D).