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. 2018 Jan 2;215(1):91–113. doi: 10.1084/jem.20171163

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© 2018 Ohsaki et al.

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Figure 6. — IC supplementation to mothers protects offspring from food allergy. (A–H) IC supplementation during pregnancy and breastfeeding. Experimental protocol (A), serum OVA-IgG1-IC in weaned offspring (B), OVA-specific Foxp3⁺ cells expanded from offspring MLN cells (C), serum OVA-IgE levels (D), core body temperature change (E), serum mMCP1 levels (F), jejunal mast cell frequencies (G), and numbers (H). (I–P) IC supplementation during breastfeeding. Experimental protocol (I), serum OVA-IgG1-IC in weaned offspring (J), OVA-specific Foxp3⁺ cells expanded from offspring MLN cells (K), serum OVA-IgE levels (L), core body temperature change (M), serum mMCP1 levels (N), jejunal mast cell frequencies (O), and numbers (P). Groups of animals were compared using the Mann-Whitney U test. Data are mean ± SEM and representative of 2 independent experiments (B–H, J–P). *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.