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. 2018 Jan 2;215(1):21–33. doi: 10.1084/jem.20171773

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© 2018 Norlander et al.

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Figure 3. — Working hypothesis for activation of renal DCs by sympathetic activation in hypertension. Hypertension enhances sympathetic outflow to the kidney, where DCs become activated, accumulate isoLG-adducts, and transmigrate to secondary lymphoid organs. T cells activated by DCs return to the kidney to promote renal dysfunction and damage. From Xiao et al. (2015).