Fig. (1).

Functional interactions between top breast cancer metastasis markers (bright blue, red) and primary breast cancer prognostic markers (pastel blue red) with the IPA-predicted upstream regulators. Highlighted in purple-regulatory circuit that may lead to development of metastatic transition. Arrows indicate activation, blocked lines-inhibition. Bright line colours correspond to regulatory interactions that potentially lead to differential expression of the metastatic markers. Dashed lines indicate predicted direct interactions between proteins, depicting protein-protein binding and regulatory actions. Validated transcriptional regulation is shown by solid lines.