Table 1.
Genes Identified by literature mining and their corresponding mRNA expression.
| Study | MMP1 | VCAM1 | FZD3 | VEGFC | COX2 | DEPDC1 | NUSAP1 | RRM2 | FOXM1 | MUC1 |
|---|---|---|---|---|---|---|---|---|---|---|
| Metastatic vs. normal breast tissue | + log2=0.15 fold=1.09 pval=0.620 |
+ log2=0.51 fold=1.59 pval=0.348 |
+ log2=2.71 fold=5.9 pval=0.006 |
- log2=-2.33 fold=-0.09 pval=0.012 |
- log2=-1.06 fold=-2.09 pval=<0.001 |
+ log2=0.24 fold=1.18 pval=0.146 |
+ log2=0.43 fold=1.42 pval=0.237 |
+ log2=1.32 fold=1.84 pval=0.398 |
+ log2=0.13 fold=1.00 pval=0.806 |
+ log2=2.50 fold=5.78 pval=0.059 |
| Metastatic vs. primary breast cancer | - log2=-2.73 fold=-14.61 pval=0.098 |
+ log2=1.72 fold=2.93 pval=0.048 |
+ log2=0.41 fold=1.11 pval=0.562 |
- log2=-0.09 fold=-1.13 pval=0.901 |
- log2=-1.04 fold=-2.08 pval=<0.001 |
- log2=-0.53 fold=-1.66 pval=0.332 |
- log2=-1.02 fold=-3.22 pval=0.368 |
- log2=-1.84 fold=-3.36 pval=0.038 |
- log2=-2.35 fold=-9.59 pval=0.076 |
- log2=-0.68 fold=-2.47 pval=0.617 |
| Primary breast cancer vs. normal breast tissue | + log2=2.87 fold=15.91 pval=0.017 |
- log2=-1.21 fold=-1.84 pval=0.039 |
+ log2=2.30 fold=5.36 pval=<0.001 |
- log2=-2.24 fold=-4.04 pval=<0.001 |
- log2=-0.02 fold=-1.00 pval=0.892 |
+ log2=0.77 fold=1.96 pval=0.056 |
+ log2=1.45 fold=4.56 pval=0.076 |
+ log2=3.16 fold=6.18 pval=<0.001 |
+ log2=2.48 fold=9.63 pval=0.012 |
+ log2=3.18 fold=14.25 pval=0.004 |
Log(2)- ratios, fold change values and p values. Log(2)-ratios (log2), fold change values (fold) and p-values (pval) from Genevestigator analysis are shown. Up-regulation of genes is indicated by (+), down-regulation of genes is indicated by (-).