Figure 1.
FXR mRNA and protein expression are decreased in human kidney biopsies with diabetes- and obesity-related kidney disease. (A) Glomerular and tubular FXR mRNA levels are decreased in kidney biopsy samples obtained from human subjects with diabetic- and obesity-related kidney disease. Glomerular and tubular cells were obtained by laser capture microdissection. (B) FXR protein expression as determined by immunohistochemistry is decreased in kidney biopsy samples obtained from human subjects with diabetic kidney disease (n=16 subjects in each group).