. 2017 Oct 31;29(1):118–137. doi: 10.1681/ASN.2017020222

Table 1.

Metabolic parameters and renal gene expression in DBA/2J mice

	CON	STZ	STZ/INT-767
Body weight, g	40.4±1.76	23.7±1.36^a	22.4±2.65
Kidney weight, g	0.54±0.03	0.65±0.06^a	0.61±0.05
Kidney weight-to-body weight ratio, %	1.33±0.09	2.73±0.28^a	2.74±0.38
Plasma glucose, mg/dl	167±9	823±15^a	882±29
Plasma TG, mg/dl	192±43	1606±242^a	744±208^b
Plasma TC, mg/dl	216±11	1337±102^a	220±24^b
Plasma HDL-C, mg/dl	71.4±2.7	91.3±17.0	89.2±2.4
Plasma LDL-C, mg/dl	14.0±2.1	654±79^a	40.5±2.5^b
Plasma insulin, ng/ml	10.58±2.17	0.22±0.02^a	0.25±0.05
Kidney fibrosis marker
TGF-β	1.19±0.05	3.53±0.28^a	2.34±0.25^b
CTGF	1.18±0.10	2.93±0.35^a	1.51±0.17^b
FSP-1	1.50±0.20	2.43±0.21^a	1.48±0.15^b
Snail	1.26±0.09	2.12±0.13^a	1.66±0.13^b
ZEB1	1.34±0.08	1.62±0.11	1.11±0.04^b
Lipid metabolism
SREBP-1c	5.74±0.60	3.96±0.27^a	1.61±0.14^b
SCD-1	3.45±0.57	2.80±0.32	1.02±0.05^b
SCD-2	0.85±0.06	1.99±0.23^a	1.12±0.14^b
ChREBPα	2.47±0.10	1.79±0.18^a	2.14±0.29
ChREBPβ	1.72±0.13	28.3±4.72^a	26.1±1.75
LPK	1.04±0.06	2.85±0.31^a	1.78±0.19^b
SREBP-2	1.86±0.09	1.71±0.11	1.26±0.11^b
HMGCOR	1.63±0.10	1.47±0.11	1.52±0.04
HMGCS-2	0.07±0.01	19.22±2.48^a	13.20±2.10
LPL	2.82±0.37	1.27±0.09^a	2.32±0.18^b
FIT-1	1.19±0.08	7.13±0.75^a	2.34±0.24^b
CD36	2.45±0.20	1.84±0.17	2.11±0.34
Proinflammatory cytokines
Cox2	8.09±1.77	27.88±4.02^a	12.14±1.49^b
ICAM-1	1.06±0.16	3.40±0.15^a	2.45±0.72^b
CD68	0.91±0.03	3.40±0.52^a	1.46±0.18^b
ER stress
GRP78	2.58±0.18	1.78±0.11^a	2.45±0.08^b
XBP-1s	4.83±0.38	1.56±0.12^a	2.29±0.14^b
Chop	2.35±0.23	4.07±0.27^a	3.41±0.56

Data are mean±SEM (n=6 mice in each group). CON, nondiabetic DBA/2J; TG, total triglycerides; TC, total cholesterol; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; LPK, liver pyruvate kinase; ICAM-1, intercellular adhesion molecule-1; GRP78, glucose regulated/binding Ig protein-78; XBP-1s, spliced form of X-box binding protein-1.

P<0.05 versus CON.

P<0.05 versus STZ.