. 2017 Oct 31;29(1):118–137. doi: 10.1681/ASN.2017020222

Table 2.

Metabolic parameters and renal gene expression in db/db mice

	db/m	db/m/INT-767	db/db	db/db/INT-767
Plasma glucose, mg/dl	198±7	227±14	892±63	807±52
Plasma TG, mg/dl	63.4±7.31	39.4±3.18^a	141.4±19.0^a	56.01±11.9^b
Plasma TC, mg/dl	84.6±4.61	42.0±2.73^a	102.3±4.12^a	39.2±2.88^b
Mitochondrial biogenesis
Nampt	1.71±0.07	1.82±0.10	1.43±0.10^a	2.04±0.19^b
Sirt1	2.66±0.16	2.64±0.11	1.44±0.10^a	2.48±0.24^b
Sirt3	1.88±0.10	2.12±0.10	1.44±0.11^a	2.44±0.41^b
PGC-1α	2.06±0.10	2.36±0.10	1.73±0.15^a	3.26±0.55^b
ERR-α	1.92±0.13	2.00±0.11	1.38±0.06^a	2.04±0.19^b
Nrf1	5.24±0.19	4.31±0.70	3.65±0.32^a	5.80±1.20^b
PDK4	1.45±0.09	1.33±0.12	2.55±0.37^a	5.76±1.05^b
CPT-1a	1.41±0.08	1.68±0.12	1.96±0.18^a	2.78±0.26^b
AceS2	1.79±0.08	2.31±0.15^a	2.03±0.21	2.51±0.37^b
LCAD	2.10±0.09	1.96±0.11	1.20±0.08^a	1.63±0.23^b
M2 macrophage markers
CD163	2.41±0.28	2.23±0.61	1.41±0.40	3.35±0.86^b
CD206	4.42±0.40	4.15±0.33	2.19±0.17^a	3.27±0.44^b

Data are mean±SEM (n=6 mice in each group). TG, total triglycerides; TC, total cholesterol; Nampt, nicotinamide phosphoribosyl transferase; PDK4, pyruvate dehydrogenase kinase 4; CPT-1a, carnitine palmitoyltransferase-1a; AceS2, acetyl CoA synthetase 2; LCAD, long-chain acyl CoA dehydrogenase.

P<0.05 versus db/m.

P<0.05 versus db/db.